Suchalatha S, Shyamala Devi C S
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, 600 025 Chennai.
Indian J Clin Biochem. 2004 Jul;19(2):184-9. doi: 10.1007/BF02894283.
To study the protective role of Arogh on isoproterenol induced myocardial damage in rats. The effect of Arogh pretreatment on isoproterenol induced myocardial damage was assessed by studying the levels of lipid peroxides and changes in the activity of marker enzymes such as creatine kinase, lactate dehydrogenase and transaminases in serum and heart tissue. In isoproterenol administered rats, a significant decrease was observed in the activity of marker enzymes in the heart with a corresponding increase in their levels in serum. Lipid peroxide levels increased significantly in the serum and heart. In rats pretreated with arogh, the level of lipid peroxides and the activity of marker enzymes were maintained at near normal values. Pretreatment with Arogh offered a protective effect against isoproterenol induced myocardial damage in rats as evidenced by LDH isoenzyme patterm and histopathological studies of heart tissue.
研究阿罗格对异丙肾上腺素诱导的大鼠心肌损伤的保护作用。通过研究血清和心脏组织中脂质过氧化物水平以及肌酸激酶、乳酸脱氢酶和转氨酶等标志物酶活性的变化，评估阿罗格预处理对异丙肾上腺素诱导的心肌损伤的影响。在给予异丙肾上腺素的大鼠中，观察到心脏中标志物酶的活性显著降低，而其在血清中的水平相应升高。血清和心脏中的脂质过氧化物水平显著升高。在用阿罗格预处理的大鼠中，脂质过氧化物水平和标志物酶的活性维持在接近正常的值。如乳酸脱氢酶同工酶模式和心脏组织的组织病理学研究所证明，阿罗格预处理对异丙肾上腺素诱导的大鼠心肌损伤具有保护作用。
