Rajaram Sri-Sujanthy, Walters Arthur S, England Sandra J, Mehta Deviyani, Nizam Farrukh
New Jersey Neuroscience Institute at JFK Medical Center and Seton Hall University School of Graduate Medical Education, Edison, NJ, USA.
Sleep. 2004 Jun 15;27(4):767-73.
Growing pains may be an important clue to the diagnosis of childhood restless legs syndrome (RLS). However, there are no previous studies to determine whether a subpopulation of children with growing pains meet the diagnostic criteria for RLS. The purpose of this study is to determine if some children with growing pains meet diagnostic criteria for RLS and to compare the polysomnographic characteristics of these children to controls. DESIGN/PARTICIPANTS/MEASUREMENTS: Eleven children from a pediatric neurology clinic with an emphasis on attention-deficit/hyperactivity disorder (ADHD) and with a diagnosis of growing pains were referred. They were interviewed with the parent to determine if their symptoms of growing pains met criteria for definite RLS. Those who met clinical criteria for RLS underwent polysomnography, and the results of their polysomnographic studies were compared to those of a control group (10 children, mean age 9.7 years).
Academic medical center.
Ten (mean age 10.4 years) of the 11 children with growing pains met clinical criteria for RLS. In 4 of 8 families of these 10 children, 1 parent had RLS. Six of the 10 children had ADHD. There were no differences in the polysomnographic findings between the growing-pain and control groups, and none of the children with RLS had what is considered to be a clinically significant number of periodic limb movements of sleep. There were no differences in the polysomnographic findings between the "growing-pain ADHD" and "growing-pain non-ADHD" subgroups. The growing pains were severe enough for the patients and family to ask for treatment in 4 cases, and carbidopa/levodopa was utilized.
Some children diagnosed with growing pains meet diagnostic criteria for RLS, and a family history of RLS is common in these children. In some cases symptoms are severe enough to warrant treatment.
生长痛可能是儿童不安腿综合征(RLS)诊断的重要线索。然而,此前尚无研究确定患有生长痛的儿童亚群是否符合RLS的诊断标准。本研究的目的是确定一些患有生长痛的儿童是否符合RLS的诊断标准,并将这些儿童的多导睡眠图特征与对照组进行比较。
设计/参与者/测量方法:从一家儿科神经科诊所转介了11名儿童,该诊所主要诊治注意力缺陷多动障碍(ADHD),这些儿童被诊断为生长痛。对他们及其家长进行了访谈,以确定他们的生长痛症状是否符合明确RLS的标准。符合RLS临床标准的儿童接受了多导睡眠图检查,并将其多导睡眠图研究结果与对照组(10名儿童,平均年龄9.7岁)的结果进行比较。
学术医疗中心。
11名患有生长痛的儿童中有10名(平均年龄10.4岁)符合RLS的临床标准。在这10名儿童的8个家庭中,有4个家庭的1名家长患有RLS。10名儿童中有6名患有ADHD。生长痛组和对照组的多导睡眠图检查结果没有差异,且患有RLS的儿童均没有被认为具有临床意义的睡眠期周期性肢体运动数量。“生长痛合并ADHD”亚组和“生长痛不合并ADHD”亚组的多导睡眠图检查结果没有差异。有4例患者的生长痛严重到患者及其家人要求治疗,使用了卡比多巴/左旋多巴。
一些被诊断为生长痛的儿童符合RLS的诊断标准,且这些儿童中RLS家族史很常见。在某些情况下,症状严重到足以进行治疗。