Hashem A N, Soliman M S, Hamed M A, Swilam N F, Lindequist U, Nawwar M A
Pharmazie. 2016 Apr;71(4):227-32.
The novel flavonoids, 2",2"'-di-O-α-rhamnopyranosyl-vicenin II, a di-C-glycosyl flavone, and herbacetin 3-O-β-xylopyranosyl- (1"' --> 2")-O-β-glucopyranoside, were isolated from the leaves of Beta vulgaris subspecies cicla L. var. flavescens, an edible plant which is consumed in the Mediterranean areas, additional to the known flavonoids, 6-C-glucosyl isoscutellarein, vitexin-(1"' --> 2")-O-β-xylopyranosyl, vitexin-(1'" --> 2")-O-α-rhamnopyranosyI and vitexin. All metabolites were established by conventional methods of analysis and their structures were confirmed by spectroscopic analysis, including 1 D and 2D-NMR and by HR-ESIMS, as well. The extract of the plant leaves shows hepatoprotective effects in rats intoxicated by administration of acetaminophen and exhibits hypolipidemic activity in rats with high-fat-diet induced hypercholesterolemia. The evaluation was done through measuring the liver function enzymes (aspartate and alanine aminotransferases and alkaline phosphatase, the lipid profile (total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and triglycerides) and histopathological analysis of liver slides.
从食用植物黄化叶用甜菜（Beta vulgaris subspecies cicla L. var. flavescens）的叶子中分离出了新型黄酮类化合物，即二 - C - 糖苷黄酮2",2"'- 二 - O - α - 鼠李糖基 - 异荭草苷II以及草本黄素3 - O - β - 木糖基 -（1"'→2"）- O - β - 葡萄糖苷，除此之外还分离出了已知的黄酮类化合物，6 - C - 葡萄糖基异黄芩素、牡荆素 -（1"'→2"）- O - β - 木糖基、牡荆素 -（1'"→2"）- O - α - 鼠李糖基和牡荆素。所有代谢产物均通过常规分析方法确定，其结构也通过光谱分析得以证实，包括一维和二维核磁共振以及高分辨电喷雾电离质谱。该植物叶子提取物对用对乙酰氨基酚中毒的大鼠显示出肝脏保护作用，并且对高脂饮食诱导的高胆固醇血症大鼠具有降血脂活性。通过测量肝功能酶（天冬氨酸和丙氨酸转氨酶以及碱性磷酸酶）、血脂谱（总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯）以及对肝脏切片进行组织病理学分析来进行评估。
