脑室内注射吗啡和依托尼秦的不同运动效应。
Differential motor effects of intraventricular infusion of morphine and etonitazene.
作者信息
Shizgal P, Sklar L S, Brown Z W, Amit Z
出版信息
Pharmacol Biochem Behav. 1977 Jan;6(1):17-20. doi: 10.1016/0091-3057(77)90154-x.
The motor effects produced by intraventricular infusions of morphine were compared to the effects of etonitazene. Despite the similarity in the peripheral actions of these drugs, motor effects of central infusions differed dramatically. Intraventricular morphine infusions resulted in explosive motor behavior whereas etonitazene produced extreme muscular rigidity. The periaqueductal grey (PAG) has been proposed as the substrate of morphine-induced explosive motor behavior. However, considerations of the dose of morphine and the mobility of this drug in tissue suggests that sites other than the PAG may also be involved in explosive motor behavior.
将脑室内注射吗啡产生的运动效应与依托尼秦的效应进行了比较。尽管这些药物在外周作用方面相似，但中枢注射的运动效应却有显著差异。脑室内注射吗啡会导致爆发性运动行为，而依托尼秦则产生极度的肌肉强直。导水管周围灰质（PAG）被认为是吗啡诱导的爆发性运动行为的基础。然而，考虑到吗啡的剂量及其在组织中的移动性，表明除PAG之外的其他部位也可能参与爆发性运动行为。
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