McMillan D E, Leander J D
Pharmacol Biochem Behav. 1976 Feb;4(2):137-41. doi: 10.1016/0091-3057(76)90005-8.
Rats were induced to drink either a saline-etonitazene solution or a saline solution with a schedule-induced polydipsia paradigm. When water was freely available, the rats continued to drink the saline solution or the saline-etonitazene solution, rather than the water. When the locations of the solutions were switched, the rats that were drinking saline switched to water (drank at the usual location), but the rats that were drinking saline-etonitazene continued to drink the saline-etonitazene solution (drank from the bottle at the other location). Naloxone administration temporarily eliminated the drinking of saline-etonitazene solution, but not that of saline solution.
采用定时诱导多饮范式，诱导大鼠饮用生理盐水-依托尼秦溶液或生理盐水。当水可自由获取时，大鼠继续饮用生理盐水或生理盐水-依托尼秦溶液，而非水。当溶液位置切换时，饮用生理盐水的大鼠改喝水（在通常位置饮水），但饮用生理盐水-依托尼秦溶液的大鼠继续饮用生理盐水-依托尼秦溶液（从另一位置的瓶子饮水）。给予纳洛酮可暂时消除大鼠对生理盐水-依托尼秦溶液的饮用，但对生理盐水的饮用无此作用。
