一名银屑病关节炎患者的滑膜组织中存在巨细胞病毒、单纯疱疹病毒1型和细小病毒B19的复制性多病毒感染以及潜伏的EB病毒感染。

Replicative multivirus infection with cytomegalovirus, herpes simplex virus 1, and parvovirus B19, and latent Epstein-Barr virus infection in the synovial tissue of a psoriatic arthritis patient.

作者信息

Mehraein Yasmin, Lennerz Carsten, Ehlhardt Sandra, Zang Klaus D, Madry Henning

机构信息

Department of Human Genetics, Saarland University, University Hospital, Bldg. 60, 66421 Homburg/Saar, Germany.

出版信息

J Clin Virol. 2004 Sep;31(1):25-31. doi: 10.1016/j.jcv.2004.02.014.

DOI:10.1016/j.jcv.2004.02.014

PMID:15288610

Abstract

BACKGROUND

Psoriatic arthropathy occurs as complicating feature in about 5-7% of psoriasis patients. Infectious mechanisms including viral antigens have been suggested by serologic data as CD8 T cellular specifity towards viral epitopes.

OBJECTIVE AND RESULTS

We here reported a case of a 32-year-old male psoriatic arthritis patient, where we could demonstrate simultaneous infection with cytomegalovirus (CMV), herpes simplex virus type I (HSV1) and parvovirus B19 (B19), as well as latent Epstein-Barr virus (EBV) infection within the synovial tissue by immunohistochemistry (CMV, parvovirus B19, HSV1, EBV-LMP) and DNA-in situ-hybridization (CMV). Serologic examination revealed positive EBV and parvovirus B19-IgG-antibodies, but no antibody response to HSV1 and CMV.

CONCLUSION

This case is of special interest, since replicative viral infections have not yet been demonstrated localised in the psoriatic arthritis synovia. Thus, with particular regard to the limited information of the serologic data and the possible need of immuno suppressive therapy direct synovial testing for viral antigenes may be considered in psoriatic arthritis patients.

摘要

背景

银屑病关节炎是约5%-7%的银屑病患者的并发症。血清学数据表明，包括病毒抗原在内的感染机制表现为CD8 T细胞对病毒表位的特异性。

目的及结果

我们在此报告了一例32岁男性银屑病关节炎患者，通过免疫组织化学（巨细胞病毒、细小病毒B19、单纯疱疹病毒1型、EB病毒潜伏膜蛋白）和DNA原位杂交（巨细胞病毒），我们证实其滑膜组织同时感染了巨细胞病毒（CMV）、单纯疱疹病毒1型（HSV1）和细小病毒B19（B19），以及潜伏的EB病毒（EBV）感染。血清学检查显示EB病毒和细小病毒B19-IgG抗体呈阳性，但对HSV1和CMV无抗体反应。