单纯疱疹病毒1型相关性先天性白内障。

Herpes simplex virus-1--associated congenital cataract.

作者信息

Raghu Hari, Subhan Shaheen, Jose Roby J, Gangopadhyay Nibaran, Bhende Jyoti, Sharma Savitri

机构信息

Jhaveri Microbiology Center, Professor Brien Holden Eye Research Center, Hyderabad Eye Research Foundation, LV Prasad Eye Institute, LV Prasad Marg, Banjara Hills, Hyderabad, India.

出版信息

Am J Ophthalmol. 2004 Aug;138(2):313-4. doi: 10.1016/j.ajo.2004.03.010.

DOI:10.1016/j.ajo.2004.03.010

PMID:15289153

Abstract

PURPOSE

To report association of herpes simplex virus-type 1 (HSV-1) in four cases of congenital cataract.

DESIGN

Prospective interventional case series.

METHODS

Four infants younger than 12 months, presenting with unilateral or bilateral congenital cataract, were included. The cases were clinically evaluated by the pediatric ophthalmologist. The lens aspirates collected at the time of cataract surgery were processed for HSV-1 culture in rabbit corneal epithelial (SIRC) cell line and for HSV-1 DNA by polymerase chain (PCR). The sera of the children and the mother were tested for HSV-1 immunoglobulin (Ig) M and IgG by enzyme linked immunosorbent assay (ELISA).

RESULTS

HSV-1 was isolated in tube cultures in three of four lens aspirates, and all four lens aspirates were positive for HSV-1 DNA by PCR. Serum HSV-1 IgM was positive in all babies and in three cases HSV-1 IgM was positive in the mother's serum.

CONCLUSION

Based on a computerized literature search, we believe this may be the first report of HSV-1 associated congenital cataract.

摘要

目的

报告4例先天性白内障与1型单纯疱疹病毒（HSV-1）的关联。

设计

前瞻性干预病例系列。

方法

纳入4例12个月以下单侧或双侧先天性白内障婴儿。由小儿眼科医生进行临床评估。白内障手术时收集的晶状体吸出物在兔角膜上皮（SIRC）细胞系中进行HSV-1培养，并通过聚合酶链反应（PCR）检测HSV-1 DNA。采用酶联免疫吸附测定（ELISA）检测患儿及其母亲血清中的HSV-1免疫球蛋白（Ig）M和IgG。