先天性白内障患儿中TORCH病原体的检测
Detection of TORCH pathogens in children with congenital cataracts.
作者信息
Lu Bin, Yang Yabo
机构信息
Department of Ophthalmology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.
Department of Ophthalmology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
出版信息
Exp Ther Med. 2016 Aug;12(2):1159-1164. doi: 10.3892/etm.2016.3348. Epub 2016 May 17.
The aim of the present study was to investigate the correlation between infection rates with TORCH pathogens including toxoplasma, rubella virus, cytomegalovirus, and herpes simplex virus (HSV) I and II and congenital cataracts. In total, the data from 69 children with congenital cataract treated at the Children's Hospital of the Zhejiang University School of Medicine between May 2006 and September 2013 were examined, including the complete serum test results for immunoglobulin (Ig)G and IgM that target TORCH pathogenic antibodies. These results were compared with the antibody levels of 5,914 children in a control group. Using SPSS 19.0 software, variance equation Levene tests, mean equation t tests, and completely randomized design of four tables χ tests were applied. The HSV II IgG positivity rates significantly differed between the cataract and control groups. These results suggested that HSV may be one of the pathogenic viruses that leads to congenital cataracts.
本研究的目的是调查弓形虫、风疹病毒、巨细胞病毒以及单纯疱疹病毒I型和II型（TORCH病原体）的感染率与先天性白内障之间的相关性。总共检查了2006年5月至2013年9月期间在浙江大学医学院附属儿童医院接受治疗的69例先天性白内障患儿的数据，包括针对TORCH病原抗体的免疫球蛋白（Ig）G和IgM的完整血清检测结果。将这些结果与对照组中5914名儿童的抗体水平进行比较。使用SPSS 19.0软件，应用方差方程Levene检验、均值方程t检验以及四格表完全随机设计χ检验。白内障组和对照组之间单纯疱疹病毒II型IgG阳性率存在显著差异。这些结果表明，单纯疱疹病毒可能是导致先天性白内障的致病病毒之一。
Zotero 插件