Cengiz L, Kiyan M, Cengiz A T, Kara F, Uğurel M S
Ankara Universitesi, Tip Fakültesi, Kadin Hastaliklari ve Doğum Anabilim Dali.
Mikrobiyol Bul. 1993 Oct;27(4):299-307.
In this study, HSV-1 IgG, IgM and HSV-2 IgG, IgM antibodies by ELISA in the sera of the mothers who had different kinds of obstetrical problems like abortus, stillbirth, prematurity, postmaturity, intrauterine development retardation and in the newborns' cord sera who had congenital anomalies like anencephaly, cataract and dolichocephaly were investigated. In these mothers HSV-1 IgG positivity ratio was 71/73 (97.3%). There was no significant difference in the age group distribution of HSV-1 IgG. The HSV-1 IgG positivity ratios in mother sera were the same as in cord sera. It was found that HSV-1 IgG antibodies passed transplacentally. It was established that one of the subjects had premature baby and the other had stillbirth inspite of HSV-1 IgG negativity but in the risk group subjects. HSV-1 IgM was found positive in 7 mothers (9.6%) of the study group. This data was the sign of active or reactive infection. There were 3 abortus, 1 stillbirth and 3 anomalous baby in HSV-1 IgM seropositive mothers. In these mothers, 65/73 (89%) HSV-2 IgG and 6/73 (8%) HSV-2 IgM seropositivity were defined. In the cord sera these ratios were 65/73 (89%) and 2/73 (2.7%). IgM seropositivity of the material of the mothers who had abortus was explained by the effect of HSV-2 activity and the presence of HSV-2 IgM, 4 mothers were noted for the active or reactive infection sign. It was understood that HSV-2 IgG passed completely via placenta and there were no significant difference between the presence of the antibody and the age group.
在本研究中，通过酶联免疫吸附测定法（ELISA）检测了患有不同产科问题（如流产、死产、早产、过期产、宫内发育迟缓）的母亲血清以及患有先天性异常（如无脑儿、白内障和长头畸形）的新生儿脐带血清中的单纯疱疹病毒1型（HSV-1）IgG、IgM抗体和单纯疱疹病毒2型（HSV-2）IgG、IgM抗体。在这些母亲中，HSV-1 IgG阳性率为71/73（97.3%）。HSV-1 IgG在年龄组分布上无显著差异。母亲血清中的HSV-1 IgG阳性率与脐带血清中的相同。发现HSV-1 IgG抗体可经胎盘传递。已确定其中一名受试者尽管HSV-1 IgG呈阴性，但仍属于风险组，产下了早产儿，另一名产下了死产儿。在研究组的7名母亲（9.6%）中发现HSV-1 IgM呈阳性。该数据表明存在活动性或反应性感染。HSV-1 IgM血清阳性的母亲中有3例流产、1例死产和3例异常婴儿。在这些母亲中，定义了65/73（89%）的HSV-2 IgG和6/73（8%）的HSV-2 IgM血清阳性。在脐带血清中，这些比率分别为65/73（89%）和2/73（2.7%）。流产母亲的材料中IgM血清阳性是由HSV-2活性的影响和HSV-2 IgM的存在所解释的，有4名母亲表现出活动性或反应性感染迹象。据了解，HSV-2 IgG完全通过胎盘传递，抗体的存在与年龄组之间无显著差异。
