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确定最小红斑剂量和比色测量作为皮肤对UV-B辐射敏感性的指标。

Determination of the minimal erythema dose and colorimetric measurements as indicators of skin sensitivity to UV-B radiation.

作者信息

Dornelles Sérgio, Goldim José, Cestari Tania

机构信息

Department of Sanitary Dermatology of the Health and Environment Department of Rio Grande do Sul, Porto Alegre, RS, Brazil.

出版信息

Photochem Photobiol. 2004 Jun;79(6):540-4. doi: 10.1562/yg-03-08.1.

Abstract

There is a strong relation between chronic UV-B-induced sunburns and the development of skin cancer. Therefore, it is important to obtain a method that can be reproduced easily to detect individuals with similar skin color but different sensitiveness to sun exposure. The study evaluated 193 healthy volunteers (68% women; the average age was 38 years). They were divided into six groups of at least 30 subjects, according to skin type. The minimal erythema dose (MED) was assessed in two non-sun-exposed areas (thorax-infra-axillary area and on the buttocks), using a UV-B source (0.5 mW/cm2), with openings of 1 cm2, in increasing doses. The same areas were evaluated with a Minolta CR 300 Chromameter (Lab* system). The MED values ranged from 13 to 156 mJ/cm2; the coordinate L* (brightness) ranged from 75.96 to 30.15. The correlation between the MED and the brightness was negative in both areas (Pearson's correlation r = -0.91, P < 0.05). Color measurements, especially brightness, can be used to quickly assess skin sensibility. Considering the MED, there is a substantial overlapping of adjacent phototypes, but they could be separated into two groups: more sensitive individuals (Types I, II, III and IV) and less sensitive ones (Types V and VI).

摘要

慢性UV - B引起的晒伤与皮肤癌的发生之间存在密切关系。因此,获得一种易于重现的方法来检测肤色相似但对阳光照射敏感性不同的个体非常重要。该研究评估了193名健康志愿者(68%为女性;平均年龄38岁)。根据皮肤类型,他们被分为六组,每组至少30名受试者。使用UV - B光源(0.5 mW/cm²),开口面积为1 cm²,以递增剂量在两个非阳光暴露区域(胸部 - 腋下区域和臀部)评估最小红斑剂量(MED)。使用美能达CR 300色差仪(Lab系统)对相同区域进行评估。MED值范围为13至156 mJ/cm²;坐标L(亮度)范围为75.96至30.15。在两个区域中,MED与亮度之间的相关性均为负(皮尔逊相关系数r = -0.91,P < 0.05)。颜色测量,尤其是亮度,可用于快速评估皮肤敏感性。考虑到MED,相邻光型之间存在大量重叠,但它们可分为两组:更敏感的个体(I型、II型、III型和IV型)和较不敏感的个体(V型和VI型)。

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