Department of Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
Department of Medicine, University Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia.
Photodermatol Photoimmunol Photomed. 2018 Nov;34(6):400-404. doi: 10.1111/phpp.12410. Epub 2018 Jul 17.
Ethnicity, skin phototype and colour influenced minimal erythema dose (MED). Sun exposure has been postulated to increase MED. We determined immediate pigment darkening dose to UVA (IPDDA), MED and minimal melanogenic dose (MMD) for UVB and UVA, and investigated factors affecting these doses.
Skin phototype was determined using Fitzpatrick phototype quiz, DSMII ColorMeter measured skin colours, sun exposure quantified using an index (SEI) and phototest performed with MEDlight-Multitester.
A total of 167 healthy volunteers participated. There were 110 (66%) females and 56 (34%) males; 124 (74.7%) were Malay, 27 (16.3%) Chinese and 14 (8.4%) Indians. One hundred and nine (65.7%) skin phototype IV, 30 (18.1%) phototype III and 27 (16.3%) phototype V. IPDDA ranges from 6 ± 1.5-5.7 ± 1.4 J/cm . MED-UVB were 96.9 ± 17.6, 124 ± 29.3 and 118.6 ± 27.4 mJ/cm for phototype III, IV and V, respectively. All MED-UVA were outside the tested dose range of 3.6-11 J/cm . MMD-UVB were 106 ± 18.2, 134 ± 25.6 and 136 ± 31.1 mJ/cm while MMD-UVA were 4.1 ± 4.1, 4.9 ± 3.8 and 5.7 ± 3.7 J/cm respectively for phototypes III, IV and V. MED-UVB, MMD-UVB and MMD-UVA did not depend on skin phototype. Facultative skin whiteness (L*), erythema (E) and melanin content (M) correlated significantly with MED-UVB while constitutive skin colours were significant for L*, yellowness (b*), E and M. Sun exposure did not significantly correlate with MED-UVB and MMDs, however, an inverse relationship with MED-UVB was demonstrated.
Minimal erythema doses in our cohort were slightly different from other regional countries. Constitutive and facultative skin whiteness, erythema and melanin content correlated with MED. There was no association between skin phototype and sun exposure with MED or MMD.
种族、肤色和肤色类型会影响最小红斑剂量（MED）。据推测，日光照射会增加 MED。本研究旨在确定中波紫外线（UVB）和长波紫外线（UVA）的即刻色素沉着增强剂量（IPDDA）、MED 和最小色素生成剂量（MMD），并探讨影响这些剂量的因素。
采用 Fitzpatrick 皮肤光型问卷确定皮肤光型，DSMII 比色计测量皮肤颜色，日光暴露指数（SEI）量化日光暴露，使用 MEDlight-Multitester 进行光测试。
共有 167 名健康志愿者参与了本研究。其中，女性 110 名（66%），男性 56 名（34%）；124 名（74.7%）为马来人，27 名（16.3%）为华人，14 名（8.4%）为印度人。109 名志愿者的皮肤光型为 IV 型（65.7%），30 名志愿者为 III 型（18.1%），27 名志愿者为 V 型（16.3%）。IPDDA 范围为 6±1.5-5.7±1.4 J/cm。MED-UVB 分别为 96.9±17.6、124±29.3 和 118.6±27.4 mJ/cm，用于 III、IV 和 V 型皮肤光型。所有 MED-UVA 均超出 3.6-11 J/cm 的测试剂量范围。MMD-UVB 分别为 106±18.2、134±25.6 和 136±31.1 mJ/cm，而 MMD-UVA 分别为 4.1±4.1、4.9±3.8 和 5.7±3.7 J/cm，用于 III、IV 和 V 型皮肤光型。MED-UVB、MMD-UVB 和 MMD-UVA 与皮肤光型无关。中波紫外线 MED 与皮肤的 facultative 白皙度（L*）、红斑（E）和黑色素含量（M）显著相关，而固有肤色与 L*、黄度（b*）、E 和 M 显著相关。日光暴露与 MED-UVB 和 MMDs 无显著相关性，但与 MED-UVB 呈负相关。
本研究队列中的最小红斑剂量与其他地区国家略有不同。固有和 facultative 皮肤白皙度、红斑和黑色素含量与 MED 相关。皮肤光型和日光暴露与 MED 或 MMD 之间无关联。
