Luck Shelley N, Turner Sally A, Rajakumar Kumar, Adler Ben, Sakellaris Harry
Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton 3800, Australia.
J Bacteriol. 2004 Aug;186(16):5551-4. doi: 10.1128/JB.186.16.5551-5554.2004.
Pathogenicity islands are capable of excision and insertion within bacterial chromosomes. We describe a protein, Rox, that stimulates excision of the Shigella resistance locus pathogenicity island in Shigella flexneri. Sequence analysis suggests that Rox belongs to a new subfamily of recombination directionality factors, which includes proteins from P4, enterohemorrhagic Escherichia coli, and Yersinia pestis.
致病岛能够在细菌染色体中进行切除和插入。我们描述了一种蛋白质Rox,它能刺激弗氏志贺菌中志贺菌抗性位点致病岛的切除。序列分析表明,Rox属于重组方向性因子的一个新亚家族,该亚家族包括来自P4噬菌体、肠出血性大肠杆菌和鼠疫耶尔森菌的蛋白质。