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福氏志贺氏菌中志贺氏菌耐药位点致病岛的切除受到重组方向性因子一个新亚组的一个成员的刺激。

Excision of the Shigella resistance locus pathogenicity island in Shigella flexneri is stimulated by a member of a new subgroup of recombination directionality factors.

作者信息

Luck Shelley N, Turner Sally A, Rajakumar Kumar, Adler Ben, Sakellaris Harry

机构信息

Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton 3800, Australia.

出版信息

J Bacteriol. 2004 Aug;186(16):5551-4. doi: 10.1128/JB.186.16.5551-5554.2004.

Abstract

Pathogenicity islands are capable of excision and insertion within bacterial chromosomes. We describe a protein, Rox, that stimulates excision of the Shigella resistance locus pathogenicity island in Shigella flexneri. Sequence analysis suggests that Rox belongs to a new subfamily of recombination directionality factors, which includes proteins from P4, enterohemorrhagic Escherichia coli, and Yersinia pestis.

摘要

致病岛能够在细菌染色体中进行切除和插入。我们描述了一种蛋白质Rox,它能刺激弗氏志贺菌中志贺菌抗性位点致病岛的切除。序列分析表明,Rox属于重组方向性因子的一个新亚家族,该亚家族包括来自P4噬菌体、肠出血性大肠杆菌和鼠疫耶尔森菌的蛋白质。

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