attP在弗氏志贺氏菌志贺氏菌抗性位点致病岛整合酶介导的整合中的作用。
Role of attP in integrase-mediated integration of the Shigella resistance locus pathogenicity island of Shigella flexneri.
作者信息
Turner Sally A, Luck Shelley N, Sakellaris Harry, Rajakumar Kumar, Adler Ben
机构信息
Department of Microbiology, Monash University, Victoria 3800, Australia.
出版信息
Antimicrob Agents Chemother. 2004 Mar;48(3):1028-31. doi: 10.1128/AAC.48.3.1028-1031.2004.
Abstract
The Shigella resistance locus (SRL) pathogenicity island (PAI) in Shigella spp. mediates resistance to streptomycin, ampicillin, chloramphenicol, and tetracycline. It can be excised from the chromosome via site-specific recombination mediated by the P4-related int gene. Here, we show that SRL PAI attP is capable of RecA-independent, site-specific, int-mediated integration into two bacterial tRNA attB sites.
摘要
志贺氏菌属中的志贺氏菌抗性位点（SRL）致病岛（PAI）介导对链霉素、氨苄青霉素、氯霉素和四环素的抗性。它可以通过由P4相关int基因介导的位点特异性重组从染色体上切除。在这里，我们表明SRL PAI attP能够独立于RecA，通过int介导的位点特异性整合到两个细菌tRNA attB位点中。
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