Bogdanovic G, Jernberg A G, Priftakis P, Grillner L, Gustafsson B
Department of Clinical Microbiology, Karolinska University Hospital Solna, Karolinska Institutet, S-171 76 Stockholm, Sweden.
Br J Cancer. 2004 Aug 31;91(5):913-5. doi: 10.1038/sj.bjc.6602099.
To investigate if children who later developed acute lymphoblastic leukaemia (ALL) were prenatally infected with HHV-6 and/or EBV, Guthrie cards taken at birth were analysed by PCR. Guthrie cards from 54 patients with ALL and 47 healthy controls matched for age and birth place were tested negative for both HHV-6 and EBV DNA. All samples contained amplifiable DNA when tested by HLA-DQ PCR. Our negative findings suggest that childhood ALL is unlikely to be associated with an in utero infection with EBV or HHV-6.
为了研究后来患急性淋巴细胞白血病(ALL)的儿童在出生前是否感染了HHV-6和/或EBV,通过聚合酶链反应(PCR)分析了出生时采集的干血斑样本。对54例ALL患者以及47例年龄和出生地相匹配的健康对照者的干血斑样本进行检测,结果显示HHV-6和EBV DNA均为阴性。通过HLA-DQ PCR检测时,所有样本均含有可扩增的DNA。我们的阴性结果表明,儿童ALL不太可能与子宫内感染EBV或HHV-6有关。