Department of Clinical Science, Intervention and Technology, Astrid Lindgren Children's Hospital, Karolinska University Hospital-Huddinge, CLINTEC, Karolinska Institutet, Stockholm, Sweden.
Br J Cancer. 2010 Mar 2;102(5):796-8. doi: 10.1038/sj.bjc.6605581.
In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards.
Guthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested polymerase chain reaction for the presence of adenovirus DNA.
Adenovirus DNA was reliably detected from only two subjects, both of whom developed ALL.
Adenovirus DNA is detected in Guthrie card samples at too low a frequency to reveal an association between adenovirus and the development of leukaemia.
为了探索儿童急性淋巴细胞白血病（ALL）的潜在病毒病因，我们对 Guthrie 卡中的常见腺病毒进行了分析。
收集了 243 名后来发展为 ALL 的儿童和 486 名匹配对照者的 Guthrie 卡，并通过巢式聚合酶链反应检测腺病毒 DNA 的存在。
仅从两名均发展为 ALL 的受试者中可靠地检测到了腺病毒 DNA。
在 Guthrie 卡样本中检测到的腺病毒 DNA 频率太低，无法揭示腺病毒与白血病发展之间的关联。
