头孢曲松对一名因皮氏罗尔斯通氏菌导致侵袭性感染的静脉吸毒者治疗失败。

Failure of ceftriaxone in an intravenous drug user with invasive infection due to Ralstonia pickettii.

作者信息

Zellweger C, Bodmer T, Täuber M G, Mühlemann K

机构信息

Division of Infectious Diseases, University Hospital, Inselspital PKT2 B, CH-3010 Bern, Switzerland.

出版信息

Infection. 2004 Aug;32(4):246-8. doi: 10.1007/s15010-004-3033-0.

DOI:10.1007/s15010-004-3033-0

PMID:15293083

Abstract

We report a case of septic arthritis due to Ralstonia pickettii in an intravenous drug user with unfavorable clinical course under antibiotic therapy with ceftriaxone despite in vitro susceptibility to the drug. The treatment failure may have been due to a discrepancy between in vitro and in vivo susceptibility of R. pickettii, or to resistance development mediated by a recently described inducible beta-lactamase.

摘要

我们报告了一例由皮氏罗尔斯通氏菌引起的脓毒性关节炎病例，患者为静脉吸毒者，尽管该菌在体外对头孢曲松敏感，但在接受头孢曲松抗生素治疗时临床病程不佳。治疗失败可能是由于皮氏罗尔斯通氏菌体外和体内药敏性之间的差异，或者是由最近描述的一种可诱导β-内酰胺酶介导的耐药性发展所致。