Maternal morbidity and obstetric complications in triplet pregnancies and quadruplet and higher-order multiple pregnancies.

作者信息

Wen Shi Wu, Demissie Kitaw, Yang Qiuying, Walker Mark C

机构信息

OMNI Research Group, Department of Obstetrics and Gynecology and Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada.

出版信息

Am J Obstet Gynecol. 2004 Jul;191(1):254-8. doi: 10.1016/j.ajog.2003.12.003.

DOI:10.1016/j.ajog.2003.12.003

PMID:15295375

Abstract

OBJECTIVE

The purpose of this study was to assess the risk of maternal morbidity and obstetric complications in women with triplet pregnancies and quadruplet and higher-order multiple pregnancies.

STUDY DESIGN

We compared the outcomes in women with triplet pregnancies (n=5491) and quadruplet and higher-order multiple pregnancies (n=423) with women with twin pregnancies (n=152,238), with the use of the 1995 to 1997 Multiple Birth File of the United States.

RESULTS

After an adjustment was made for important confounding factors, the risks of pregnancy-associated hypertension and eclampsia, anemia, diabetes mellitus, abruptio placenta, premature rupture of membrane, and cesarean delivery were increased in women with triplet pregnancies and quadruplet and higher-order multiple gestations than in women with twin pregnancies. A dose-response relationship was observed for pregnancy-associated hypertension, diabetes mellitus, and placental abruption, with higher odds ratios in women with quadruplet and higher-order multiple gestations than in women with triplet pregnancies.

CONCLUSION

The risks of maternal morbidity and obstetric complications are increased in triplet pregnancies and quadruplet and higher-order multiple pregnancies than in twin pregnancies; for certain outcomes, there is a dose-response relationship.

摘要