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双胎妊娠合并子痫前期的研究进展综述

A Review of Research Progress of Pregnancy with Twins with Preeclampsia.

作者信息

Wang Ying, Wu Na, Shen Haitao

机构信息

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.

Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.

出版信息

Risk Manag Healthc Policy. 2021 May 18;14:1999-2010. doi: 10.2147/RMHP.S304040. eCollection 2021.

Abstract

Preeclampsia has a significant long-term effect on the health of both mothers and babies. Preeclampsia-related pregnancy complications increase the morbidity and mortality of pregnant women and their fetuses by 5-8%. The recent advancement of assisted reproductive technology, combined with a rise in the number of elderly pregnant women, has resulted in pregnancy incidence with twins. Twins pregnant women have a 2-3 times greater risk of developing preeclampsia than singleton pregnant women, and it happens sooner and progresses faster. It is more severe and may appear in an atypical way. End-organ damage, such as renal failure, stroke, cardiac arrest, pulmonary edema, placental abruption, and cesarean section, are related maternal complications. Fetal growth retardation, stillbirth, and premature delivery with obstetric signs are all fetal complications. According to studies, all multiple pregnancies can take low-dose aspirin (60-150 mg) to minimize the risk of preeclampsia. To improve pregnancy outcomes and reduce the inherent risk of pregnancy with twins, twins should be handled as a high-risk pregnancy and treated differently than singletons. The literature on twin pregnancy with preeclampsia is the subject of this review. It will examine the current state of research on preeclampsia in pregnancy with twins, including the occurrence, diagnosis, and pathophysiological process. Moreover, the effect of pregnancy with twins on the perinatal outcome and pregnancy management of pregnancy with twins, including blood pressure management and preeclampsia prevention and treatment, is examined in this literature review. The goal is to figure out what kind of diagnosis and care you may need.

摘要

子痫前期对母亲和婴儿的健康都有重大的长期影响。与子痫前期相关的妊娠并发症使孕妇及其胎儿的发病率和死亡率增加5-8%。辅助生殖技术的最新进展,加上高龄孕妇数量的增加,导致了双胎妊娠的发生率上升。双胎孕妇患子痫前期的风险比单胎孕妇高2-3倍,且发病更早、进展更快。病情更严重,可能以非典型方式出现。肾衰竭、中风、心脏骤停、肺水肿、胎盘早剥和剖宫产等终末器官损伤是相关的母体并发症。胎儿生长受限、死产和伴有产科体征的早产均为胎儿并发症。根据研究,所有多胎妊娠都可服用低剂量阿司匹林(60-150毫克)以降低子痫前期的风险。为改善妊娠结局并降低双胎妊娠的固有风险,双胎妊娠应作为高危妊娠处理,与单胎妊娠区别对待。本综述的主题是关于子痫前期双胎妊娠的文献。它将审视双胎妊娠子痫前期的研究现状,包括其发生、诊断和病理生理过程。此外,本综述还探讨了双胎妊娠对围产期结局的影响以及双胎妊娠的妊娠管理,包括血压管理和子痫前期的预防与治疗。目的是弄清楚可能需要何种诊断和护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cbc/8140947/1298b0b48474/RMHP-14-1999-g0001.jpg

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