鸡胚中神经命运的获得。

The acquisition of neural fate in the chick.

作者信息

Wittler Lars, Kessel Michael

机构信息

Department of Molecular Cell Biology, Max-Planck-Institut für biophysikalische Chemie, Am Fassberg 11, 37077 Göttingen, Germany.

出版信息

Mech Dev. 2004 Sep;121(9):1031-42. doi: 10.1016/j.mod.2004.05.004.

DOI:10.1016/j.mod.2004.05.004

PMID:15296969

Abstract

Neural development in the chick embryo is now understood in great detail on a cellular and a molecular level. It begins already before gastrulation, when a separation of neural and epidermal cell fates occurs under the control of FGF and BMP/Wnt signalling, respectively. This early specification becomes further refined around the tip of the primitive streak, until finally the anterior-posterior level of the neuroectoderm becomes established through progressive caudalization. In this review we focus on processes in the chick embryo and put classical and more recent molecular data into a coherent scenario.

摘要

目前，在细胞和分子水平上，人们对鸡胚的神经发育已经有了非常详细的了解。它在原肠胚形成之前就已经开始了，当时神经和表皮细胞命运的分离分别在FGF和BMP/Wnt信号的控制下发生。这种早期的特化在原条末端周围进一步细化，直到最终通过渐进的尾化建立神经外胚层的前后水平。在这篇综述中，我们专注于鸡胚中的过程，并将经典的和最新的分子数据整合到一个连贯的场景中。