肝脏再生增强因子的结晶及初步晶体学数据
Crystallization and preliminary crystallographic data for the augmenter of liver regeneration.
作者信息
Rose J P, Wu C K, Francavilla A, Prelich J G, Iacobellis A, Hagiya M, Rao A S, Starzl T E, Wang B C
机构信息
Department of Biochemistry and Molecular Biology, University of Georgia, Athens 30602, USA.
出版信息
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):331-4. doi: 10.1107/S0907444996014084.
A new cellular growth factor termed augmenter of liver regeneration (ALR) has been crystallized. ALR has been shown to have a proliferative effect on liver cells while at the same time producing an immunosuppressive effect on liver-resident natural killer cells and liver-resident mononuclear leukocytes. In addition, ALR appears to play an important role in the synthesis and stabilization of mitochondrial gene transcripts in actively regenerating cells. ALR crystals diffract to beyond 2 A resolution and belong to space group P2(1)2(1)2, with a = 125.1, b = 108.1 and c = 38.5 A. Based on four molecules per asymmetric unit, the Matthews coefficient is calculated to be 2.16 A(3) Da(-1) which corresponds to a solvent content of 43%.
一种名为肝脏再生增强因子（ALR）的新型细胞生长因子已被结晶。研究表明，ALR对肝细胞具有增殖作用，同时对肝脏驻留自然杀伤细胞和肝脏驻留单核白细胞产生免疫抑制作用。此外，ALR似乎在活跃再生细胞中线粒体基因转录本的合成和稳定中发挥重要作用。ALR晶体的衍射分辨率超过2埃，属于空间群P2(1)2(1)2，a = 125.1，b = 108.1，c = 38.5埃。基于每个不对称单元有四个分子，计算出的马修斯系数为2.16埃³道尔顿⁻¹，对应于43%的溶剂含量。
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