Huw L Y, Goldsborough A S, Willison K, Artzt K
Department of Zoology, University of Texas at Austin 78712-1064, USA.
Dev Biol. 1995 Jul;170(1):183-94. doi: 10.1006/dbio.1995.1206.
Transmission ratio distortion (TRD) in mouse t-haplotypes remains the most significant example of meiotic drive in vertebrates. While the underlying mechanism that fuels it is still mysterious, TRD is clearly a complex multigene phenomenon. The characterization of Tctex2 (t-complex testis expressed 2) shows it to be one of several candidates for involvement in TRD. Tctex2 maps to the t-complex and encodes a membrane-associated protein found exclusively on the sperm tail. The t-haplotype form of Tctex2 is aberrant in both the level of its expression and its primary amino acid sequence, but is nonetheless translated and transported to its normal location. The multiple amino acid changes in the t-form make it extremely unlikely that it can function normally and, since it is found on sperm tails, suggest that it may actively interfere with the development of normal gamete function in males. The possible role of Tctex2 in t-complex transmission ratio distortion and sterility is discussed.
小鼠t单倍型中的传递比率畸变（TRD）仍然是脊椎动物减数分裂驱动的最显著例子。尽管驱动其发生的潜在机制仍然神秘，但TRD显然是一种复杂的多基因现象。对Tctex2（t复合体睾丸表达2）的表征表明它是参与TRD的几个候选基因之一。Tctex2定位于t复合体，编码一种仅在精子尾部发现的膜相关蛋白。Tctex2的t单倍型形式在其表达水平和一级氨基酸序列上均异常，但仍能被翻译并转运到其正常位置。t形式中的多个氨基酸变化使其极不可能正常发挥功能，并且由于它存在于精子尾部，这表明它可能会积极干扰雄性正常配子功能的发育。本文讨论了Tctex2在t复合体传递比率畸变和不育中的可能作用。
