Astur Robert S, Constable R Todd
Department of Diagnostic Radiology, Yale University, New Haven, CT 06106, USA.
Behav Neurosci. 2004 Aug;118(4):667-75. doi: 10.1037/0735-7044.118.4.667.
The hippocampus (HPC) has an essential role in relational memory. One task used to test relational memory is the transverse patterning (TP) problem (A+ B-, B+ C-, and C+ A-), which is sensitive to HPC damage across species. Using functional magnetic resonance imaging in humans, the authors observed activation maps and time course data indicating that the HPC is involved in this task, but it is paradoxically less active during the hippocampal-dependent relational memory phase relative to both a hippocampal-independent control memory phase and to a fixation control phase. This suggests that traditional assumptions suggesting that brain regions critical for a task must produce an increased blood oxygen level-dependent response during performance of that task are probably inaccurate and alternative explanations should be entertained.
海马体(HPC)在关系记忆中起着至关重要的作用。用于测试关系记忆的一项任务是横向模式(TP)问题(A + B-,B + C-,以及C + A-),该问题对跨物种的海马体损伤敏感。作者通过对人类进行功能磁共振成像,观察到激活图和时间进程数据,表明海马体参与了这项任务,但矛盾的是,在依赖海马体的关系记忆阶段,相对于不依赖海马体的对照记忆阶段和注视对照阶段,海马体的活跃度更低。这表明,传统假设认为对一项任务至关重要的脑区在执行该任务期间必须产生增加的血氧水平依赖反应,这可能是不准确的,应该考虑其他解释。