Rattan Suresh I S
Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus-C, Denmark.
J Gerontol A Biol Sci Med Sci. 2004 Jul;59(7):705-9. doi: 10.1093/gerona/59.7.b705.
The phenomenon of hormesis is represented by mild stress-induced stimulation of maintenance and repair pathways resulting in beneficial effects for the cells and organisms. Anti-aging and life-prolonging effects of a wide variety of the so-called stressors, such as pro-oxidants, aldehydes, calorie restriction, irradiation, heat shock, and hypergravity, have been reported. Molecular mechanisms of hormesis due to different stresses are yet to be elucidated, but there are indications that relatively small individual hormetic effects become biologically amplified resulting in the collective significant improvement of cellular and organismic functions and survival. Accepting that some important issues with respect to establishing the optimal hormetic conditions still need to be resolved by future research, hormesis appears to be a promising and effective approach for modulating aging, for preventing or delaying the onset of age-related diseases, and for improving quality of life in old age.
兴奋效应的现象表现为轻度应激诱导维持和修复途径的刺激，从而对细胞和生物体产生有益影响。据报道，多种所谓的应激源，如促氧化剂、醛类、热量限制、辐射、热休克和超重力，具有抗衰老和延长寿命的作用。不同应激引起兴奋效应的分子机制尚待阐明，但有迹象表明，相对较小的个体兴奋效应会在生物学上放大，从而使细胞和机体功能及存活率得到显著的整体改善。尽管未来研究仍需解决一些与确定最佳兴奋效应条件相关的重要问题，但兴奋效应似乎是一种有前景且有效的方法，可用于调节衰老、预防或延缓与年龄相关疾病的发生以及改善老年生活质量。
