Rattan Suresh Is
Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Aarhus-C, Denmark.
Hum Exp Toxicol. 2008 Feb;27(2):151-4. doi: 10.1177/0960327107083409.
Aging is characterized by stochastic accumulation of molecular damage, progressive failure of maintenance and repair, and consequent onset of age-related diseases. Applying hormesis in aging research and therapy is based on the principle of stimulation of maintenance and repair pathways by repeated exposure to mild stress. Studies on the beneficial biological effects of repeated mild heat shock on human cells in culture, and other studies on the anti-aging and life-prolonging effects of proxidants, hypergravity, irradiation and ethanol on cells and organisms suggest that hormesis as an antiaging and gerontomodulatory approach has a promising future. Its clinical applications include prevention and treatment of diabetes, cataract, osteoporosis, dementia and some cancers.
衰老的特征是分子损伤的随机积累、维持和修复功能的逐渐衰退，以及随之而来的与年龄相关疾病的发生。在衰老研究和治疗中应用 hormesis 是基于通过反复暴露于轻度应激来刺激维持和修复途径的原理。对培养的人类细胞反复进行轻度热休克的有益生物学效应的研究，以及对氧化剂、超重力、辐射和乙醇对细胞和生物体的抗衰老和延长寿命效应的其他研究表明，hormesis 作为一种抗衰老和老年调节方法具有广阔的前景。其临床应用包括预防和治疗糖尿病、白内障、骨质疏松症、痴呆症和某些癌症。
