Neurology. 2004 Aug 10;63(3):547-9. doi: 10.1212/01.wnl.0000133403.30559.ff.
Minocycline is an antibiotic with anti-inflammatory and antiapoptotic properties that prolongs survival in a transgenic Huntington disease (HD) mouse model. In a double-blind, randomized, placebo-controlled study of minocycline in 60 HD patients, the authors determined that over 8 weeks, minocycline at 100 and 200 mg/day was well tolerated and safe in HD patients. Tolerability and adverse event frequency were similar between treatment and placebo groups.
米诺环素是一种具有抗炎和抗凋亡特性的抗生素，可延长转基因亨廷顿病（HD）小鼠模型的生存期。在一项针对60名HD患者的米诺环素双盲、随机、安慰剂对照研究中，作者确定，在8周时间里，HD患者对每日100毫克和200毫克的米诺环素耐受性良好且安全。治疗组和安慰剂组的耐受性和不良事件发生率相似。
