对抗菌药物耐药的病原体：流行病学、分子机制及临床管理

Pathogens resistant to antimicrobial agents: epidemiology, molecular mechanisms, and clinical management.

作者信息

Kaye Keith S, Engemann John J, Fraimow Henry S, Abrutyn Elias

机构信息

Department of Medicine, Duke University Medical Center, Box 3152, Durham, NC 27710, USA.

出版信息

Infect Dis Clin North Am. 2004 Sep;18(3):467-511, viii. doi: 10.1016/j.idc.2004.04.003.

DOI:10.1016/j.idc.2004.04.003

PMID:15308273

Abstract

Resistance to antimicrobial drugs is increasing at an alarming rate among both gram-positive and gram-negative bacteria. Traditionally, bacteria resistant to multiple antimicrobial agents have been restricted to the nosocomial environment. A disturbing trend has been the recent emergence and spread of resistant pathogens and resistance traits in nursing homes, the community, as well as in hospitals. This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs.

摘要

革兰氏阳性菌和革兰氏阴性菌对抗菌药物的耐药性正以惊人的速度增加。传统上，对多种抗菌药物耐药的细菌一直局限于医院环境。一个令人不安的趋势是，耐药病原体和耐药特性最近在疗养院、社区以及医院中出现并传播。本文综述了对抗菌药物耐药的病原体的流行病学、耐药分子机制及治疗选择。