抗菌药物在肾衰竭中的应用。
Use of antibacterial agents in renal failure.
作者信息
Livornese Lawrence L, Slavin Dorothy, Gilbert Brett, Robbins Paul, Santoro Jerome
机构信息
Department of Medicine, Drexel University College of Medicine, 2900 W. Queen Lane, Philadelphia, PA 19129, USA.
出版信息
Infect Dis Clin North Am. 2004 Sep;18(3):551-79, viii-ix. doi: 10.1016/j.idc.2004.04.013.
This article provides background information on the pharmacokinetics of antibacterial agents in patients with normal and impaired renal function. Tables are provided to allow quick determination of appropriate dosages for varying degrees of renal failure. The use of serum levels, newer strategies for cefazolin, vancomycin, and aminoglycoside dosing, methods of dialysis and associated antibiotics dosage adjustments, and antibiotic toxicity in renal failure are reviewed.
本文提供了关于肾功能正常和受损患者抗菌药物药代动力学的背景信息。文中给出了表格，以便快速确定不同程度肾衰竭患者的合适剂量。文中还综述了血清水平的应用、头孢唑林、万古霉素和氨基糖苷类药物给药的新策略、透析方法及相关抗生素剂量调整，以及肾衰竭时的抗生素毒性。
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