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胎儿酒精综合征和胎儿酒精影响中不良生活结局的风险因素。

Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects.

作者信息

Streissguth Ann P, Bookstein Fred L, Barr Helen M, Sampson Paul D, O'Malley Kieran, Young Julia Kogan

机构信息

Department of Psychiatry and Behavioral Sciences, Fetal Alcohol & Drug Unit, University of Washington School of Medicine, Seattle, Washington 98195, USA.

出版信息

J Dev Behav Pediatr. 2004 Aug;25(4):228-38. doi: 10.1097/00004703-200408000-00002.

Abstract

Clinical descriptions of patients with Fetal Alcohol Syndrome (FAS) and Fetal Alcohol Effects (FAE) suggest major problems with adaptive behavior. Five operationally defined adverse outcomes and 18 associated risk/protective factors were examined using a Life History Interview with knowledgeable informants of 415 patients with FAS or FAE (median age 14 years, range 6-51; median IQ 86, range 29-126). Eighty percent of these patients were not raised by their biological mothers. For adolescents and adults, the life span prevalence was 61% for Disrupted School Experiences, 60% for Trouble with the Law, 50% for Confinement (in detention, jail, prison, or a psychiatric or alcohol/drug inpatient setting), 49% for Inappropriate Sexual Behaviors on repeated occasions, and 35% for Alcohol/Drug Problems. The odds of escaping these adverse life outcomes are increased 2- to 4-fold by receiving the diagnosis of FAS or FAE at an earlier age and by being reared in good stable environments.

摘要

胎儿酒精综合征(FAS)和胎儿酒精影响(FAE)患者的临床描述表明其适应性行为存在重大问题。通过对415名FAS或FAE患者(中位年龄14岁,范围6 - 51岁;中位智商86,范围29 - 126)的知情者进行生活史访谈,研究了五个操作性定义的不良结局和18个相关风险/保护因素。这些患者中有80%不是由其亲生母亲抚养长大。对于青少年和成年人,在学校经历中断的终生患病率为61%,违法问题为60%,被监禁(在拘留所、监狱、精神病院或酒精/药物住院环境中)为50%,多次出现不当性行为为49%,酒精/药物问题为35%。在较小年龄被诊断为FAS或FAE以及在良好稳定的环境中成长,可使避免这些不良生活结局的几率增加2至4倍。

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