Hamad M, Abu-Elteen K H, Ghaleb M
Department of Biological Sciences, Faculty of Science, Hashemite University, Zarqa, Jordan.
Mycoses. 2004 Aug;47(7):304-9. doi: 10.1111/j.1439-0507.2004.00994.x.
The capacity of estrogen to induce vaginal candidosis (VC) in the absence of previous or concurrent Candida albicans infections was examined. Adult female Balb/c mice were evaluated for vaginal C. albicans burden, C. albicans-specific delayed type hypersensitivity (DTH) responses and vaginal lymphocyte population kinetics at several time-points while receiving weekly injections of 0.5 mg estrogen. Estrogen treatment resulted in the appearance of significant levels of C. albicans vaginal colonization, which persisted for a period of 4 weeks. A marked suppression of DTH responses mounted against subsequent C. albicans challenge was observed. Absolute number of vaginal T lymphocytes gradually increased by several folds especially at weeks 5-6 following the start of estrogen treatment. These results clearly indicate that estrogen, independent of other predisposing factors, is capable of perturbing the commensal relationship between the host and the fungus, which results in the induction of persistent VC.
研究了雌激素在无既往或并发白色念珠菌感染情况下诱发阴道念珠菌病（VC）的能力。对成年雌性Balb/c小鼠在接受每周一次0.5mg雌激素注射的几个时间点，评估其阴道白色念珠菌负荷、白色念珠菌特异性迟发型超敏反应（DTH）以及阴道淋巴细胞群体动力学。雌激素治疗导致出现显著水平的白色念珠菌阴道定植，这种定植持续了4周。观察到对随后白色念珠菌攻击产生的DTH反应受到明显抑制。阴道T淋巴细胞的绝对数量逐渐增加了几倍，尤其是在雌激素治疗开始后的第5 - 6周。这些结果清楚地表明，雌激素独立于其他易感因素，能够扰乱宿主与真菌之间的共生关系，从而导致持续性VC的诱发。
