Richter Joel D
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Neuron. 2004 Aug 19;43(4):442-3. doi: 10.1016/j.neuron.2004.08.004.
Specific mRNAs are transported to dendrites where their translation may modify synaptic plasticity. In this issue of Neuron, Kanai et al. use affinity chromatography and mass spectrometry to identify a large number of new factors that associate with kinesin, a molecular motor, and employ siRNA technology to demonstrate their importance for RNA transport in neurons.
特定的信使核糖核酸（mRNA）被转运至树突，在那里它们的翻译可能会改变突触可塑性。在本期《神经元》杂志中，金井等人利用亲和层析法和质谱分析法，鉴定出大量与分子马达驱动蛋白相关的新因子，并运用小干扰RNA（siRNA）技术来证明它们对神经元中RNA转运的重要性。
