RNA转运（部分）揭秘！

RNA transport (partly) revealed!

作者信息

Richter Joel D

机构信息

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

出版信息

Neuron. 2004 Aug 19;43(4):442-3. doi: 10.1016/j.neuron.2004.08.004.

DOI:10.1016/j.neuron.2004.08.004

PMID:15312643

Abstract

Specific mRNAs are transported to dendrites where their translation may modify synaptic plasticity. In this issue of Neuron, Kanai et al. use affinity chromatography and mass spectrometry to identify a large number of new factors that associate with kinesin, a molecular motor, and employ siRNA technology to demonstrate their importance for RNA transport in neurons.

摘要

特定的信使核糖核酸（mRNA）被转运至树突，在那里它们的翻译可能会改变突触可塑性。在本期《神经元》杂志中，金井等人利用亲和层析法和质谱分析法，鉴定出大量与分子马达驱动蛋白相关的新因子，并运用小干扰RNA（siRNA）技术来证明它们对神经元中RNA转运的重要性。