超越从头蛋白质设计——非天然折叠寡聚体的从头设计。

Beyond de novo protein design--de novo design of non-natural folded oligomers.

作者信息

Cheng Richard P

机构信息

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, USA.

出版信息

Curr Opin Struct Biol. 2004 Aug;14(4):512-20. doi: 10.1016/j.sbi.2004.07.001.

DOI:10.1016/j.sbi.2004.07.001

PMID:15313247

Abstract

The mystery of how a protein sequence specifies a unique structure has intrigued chemists, leading to the design and study of foldamers, non-natural oligomeric molecules that adopt well-defined structures. Recently, the sequence specificity of the various regular repeating structures has been revealed for bioinspired foldamers and such foldamers have been created to adopt helical bundle tertiary structures. One major strategy for the generation of abiotic foldamers has involved molecular design of the monomer geometry. These advances in foldamer research may lead to future applications in biomedical and materials science.

摘要

蛋白质序列如何指定独特结构的谜团一直吸引着化学家，促使他们设计和研究折叠体，即具有明确结构的非天然寡聚分子。最近，受生物启发的折叠体已揭示出各种规则重复结构的序列特异性，并且已创造出此类折叠体以采用螺旋束三级结构。生成非生物折叠体的一种主要策略涉及单体几何形状的分子设计。折叠体研究的这些进展可能会在生物医学和材料科学领域带来未来的应用。