Dupont S, Mallefet J, Vanderlinden C
Laboratory of Marine Biology and Biodiversity Research Centre, Université catholique de Louvain, Bâtiment Kellner, 3 Place Croix du Sud, 1348 Louvain-la-Neuve, Belgium.
Comp Biochem Physiol C Toxicol Pharmacol. 2004 May;138(1):59-66. doi: 10.1016/j.cca.2004.04.007.
The role of adrenaline in the nervous control of bioluminescence in three brittlestar species, Amphiura filiformis, Amphipholis squamata, and Ophiopsila aranea, was assessed by testing two different beta-adrenergic antagonists (propranolol and labetalol) over a wide concentration range (10(-10)-10(-3)M). We compared the effects of analogues (active vs. inactive) of the same substance (L- and D-enantiomers of propranolol). Propranolol presented both specific and nonspecific effects: (i) nonspecific effects were observed at the higher concentrations tested (10(-4) and 10(-3)M) in all three species; (ii) specific effects were detected only at the lower concentrations tested (10(-6)-10(-5)M). In A. squamata, the involvement of adrenaline in the nervous control of luminescence is supported by propranolol and labetolol specific inhibition. The neuropharmacological implications of nonspecific effects, the involvement of adrenaline and the interspecific differences in the brittlestar nervous control of bioluminescence are discussed.
通过在较宽浓度范围（10⁻¹⁰ - 10⁻³M）内测试两种不同的β-肾上腺素能拮抗剂（普萘洛尔和拉贝洛尔），评估了肾上腺素在三种蛇尾类动物（丝状辐蛇尾、鳞蛇尾和蛛网蛇尾）生物发光神经控制中的作用。我们比较了同一物质（普萘洛尔的L-和D-对映体）类似物（活性与非活性）的效果。普萘洛尔呈现出特异性和非特异性效应：（i）在所有三个物种中，在测试的较高浓度（10⁻⁴和10⁻³M）下观察到非特异性效应；（ii）仅在测试的较低浓度（10⁻⁶ - 10⁻⁵M）下检测到特异性效应。在鳞蛇尾中，普萘洛尔和拉贝洛尔的特异性抑制支持了肾上腺素参与发光的神经控制。讨论了非特异性效应的神经药理学意义、肾上腺素的参与以及蛇尾生物发光神经控制中的种间差异。
