Jawien A, Bowen-Pope D F, Lindner V, Schwartz S M, Clowes A W
Department of Surgery, University of Washington School of Medicine, Seattle 98195.
J Clin Invest. 1992 Feb;89(2):507-11. doi: 10.1172/JCI115613.
Platelet-derived growth factor (PDGF) is a mitogen and chemoattractant for vascular smooth muscle cells (SMC) in vitro, but its activities in vivo remain largely undefined. We infused recombinant PDGF-BB (0.01-0.30 mg/kg per d i.v.) into rats subjected to carotid injury. PDGF-BB produced a small increase (two- to threefold) in medial SMC proliferation. More importantly, PDGF-BB greatly increased (20-fold) the intimal thickening and the migration of SMC from the media to the intima during the first 7 d after injury. These data provide support for the hypothesis that PDGF, and perhaps other platelet factors, might play an important role in the movement of mesenchymal cells into zones of injury undergoing repair.
血小板衍生生长因子（PDGF）在体外是血管平滑肌细胞（SMC）的促有丝分裂剂和趋化因子，但其在体内的活性在很大程度上仍不明确。我们将重组PDGF - BB（每天静脉注射0.01 - 0.30毫克/千克）注入遭受颈动脉损伤的大鼠体内。PDGF - BB使中膜SMC增殖略有增加（两到三倍）。更重要的是，在损伤后的前7天，PDGF - BB使内膜增厚以及SMC从内膜向中膜的迁移大幅增加（20倍）。这些数据支持了以下假说，即PDGF以及或许其他血小板因子可能在间充质细胞向正在进行修复的损伤区域移动中起重要作用。
