单核细胞和中性粒细胞对血小板衍生生长因子的趋化作用。
Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.
作者信息
Deuel T F, Senior R M, Huang J S, Griffin G L
出版信息
J Clin Invest. 1982 Apr;69(4):1046-9. doi: 10.1172/jci110509.
Abstract
The platelet-derived growth factor (PDGF) is shown to be chemotactic for monocytes and neutrophils. Maximum monocyte chemotaxis to PDGF is fully equal to that achieved with C5a and occurs at congruent to 20 ng/ml (congruent to 0.7 nM). Maximum neutrophil chemotaxis is congruent to 60% that achieved with C5A but occurs at congruent to 1 ng/ml (congruent to 32 pM). The chemotactic activity of PDGF is blocked by specific antisera to PDGF and by protamine sulfate, a competitive inhibitor of PDGF binding to cell surfaces. In contrast to PDGF, epidermal growth factor shows no chemotactic activity for inflammatory cells at 0.5-100 ng/ml. The high level of chemotactic activity of PDGF suggests that in addition to its role as a mitogen for smooth muscle cells and fibroblasts, PDGF may be involved in attracting inflammatory cells to sites of platelet release.
摘要
血小板衍生生长因子（PDGF）对单核细胞和中性粒细胞具有趋化作用。单核细胞对PDGF的最大趋化作用与对C5a的趋化作用完全相同，在约20 ng/ml（约0.7 nM）时出现。中性粒细胞的最大趋化作用约为对C5A趋化作用的60%，但在约1 ng/ml（约32 pM）时出现。PDGF的趋化活性被针对PDGF的特异性抗血清和硫酸鱼精蛋白阻断，硫酸鱼精蛋白是PDGF与细胞表面结合的竞争性抑制剂。与PDGF相反，表皮生长因子在0.5 - 100 ng/ml时对炎症细胞无趋化活性。PDGF的高趋化活性表明，除了作为平滑肌细胞和成纤维细胞的有丝分裂原的作用外，PDGF可能还参与将炎症细胞吸引到血小板释放部位。
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