Lau Susanna K P, Woo Patrick C Y, Woo Gibson K S, Fung Ami M Y, Wong Michelle K M, Chan King-Man, Tam Dorothy M W, Yuen Kwok-Yung
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong.
Diagn Microbiol Infect Dis. 2004 Aug;49(4):255-63. doi: 10.1016/j.diagmicrobio.2004.04.012.
Eggerthella, one of the human gut flora, was rarely reported to cause bacteremia in the literature. We describe the application of 16S ribosomal RNA gene sequencing in defining the epidemiology and clinical significance of Eggerthella bacteremia during a 4-year period. Among 55 clinically significant blood culture isolates of anaerobic Gram-positive bacilli, 5 were identified as E. lenta and 5 belonged to 2 novel Eggerthella species, proposed as E. hongkongensis and E. sinensis, respectively. The 10 patients with Eggerthella bacteremia were adults, and 9 had underlying diseases. In all cases, the source of the bacteremia was likely from endogenous flora. Septic shock was a complication in 4 patients, and 3 patients died. The present study suggests that Eggerthella bacteremia is much more common than expected and is associated with significant morbidity and mortality. Moreover, the 2 novel species account for half of the cases of Eggerthella bacteremia.
迟缓埃格特菌是人体肠道菌群之一，在文献中很少有关于其引起菌血症的报道。我们描述了16S核糖体RNA基因测序在确定4年期间迟缓埃格特菌菌血症的流行病学和临床意义方面的应用。在55株具有临床意义的厌氧革兰氏阳性杆菌血培养分离株中，5株被鉴定为迟缓埃格特菌，5株属于2个新的埃格特菌物种，分别命名为香港埃格特菌和中华埃格特菌。10例迟缓埃格特菌菌血症患者均为成年人，9例有基础疾病。在所有病例中，菌血症的来源可能是内源性菌群。4例患者出现感染性休克，3例患者死亡。本研究表明，迟缓埃格特菌菌血症比预期更为常见，且与显著的发病率和死亡率相关。此外，这2个新物种占迟缓埃格特菌菌血症病例的一半。
