Shi Yujiang, Shi Yang
Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA.
Trends Genet. 2004 Sep;20(9):445-52. doi: 10.1016/j.tig.2004.07.004.
Recent discoveries of the participation of metabolic enzymes (or homologs) and metabolic cofactors in transcriptional regulation raise the exciting possibility of a direct link between cellular metabolism and regulated gene expression. These findings also pose intriguing mechanistic questions. For instance, are the enzymatic activities of the metabolic enzymes important for transcriptional regulation? Are the homologs of those metabolic enzymes in fact enzymes? If so what are the exact roles of the enzymatic activities in transcriptional regulation? Finally, what is the role of the metabolic cofactors in gene transcription? In this article, we focus on the recent advances in deciphering the roles and mechanisms of action of metabolic cofactors and enzymes in regulated transcription.
近期关于代谢酶（或其同源物）及代谢辅助因子参与转录调控的发现，引发了细胞代谢与基因表达调控之间存在直接联系的令人兴奋的可能性。这些发现也提出了有趣的机制问题。例如，代谢酶的酶活性对转录调控是否重要？那些代谢酶的同源物实际上是否为酶？如果是，酶活性在转录调控中的确切作用是什么？最后，代谢辅助因子在基因转录中的作用是什么？在本文中，我们聚焦于在解读代谢辅助因子和酶在调控转录中的作用及作用机制方面的最新进展。
