Bourdon L, Buguet A
Département des facteurs humains, Centre de recherches du service de santé des armées Emile Pardé, BP 87, 38702 La Tronche Cedex, France.
J Fr Ophtalmol. 2004 Sep;27 Spec No 2:2S5-2S10.
Most biological activities fluctuate throughout the day and contribute to a better adaptation to the organism's daily activity. During the last 30 Years, chronobiology has aimed at studying these biological rhythms, explaining most of the biological mechanisms of i) the endogenous circadian rhythmicity, ii) the neurophysiological mechanisms of the photic system that allows its external resetting, and iii) the neuroendocrine mechanisms of internal rhythm synchronization. Moreover, the description of specific biological rhythm disorders and rhythm problems at the cellular and even the molecular level have prompted the emerging fields of chronopharmacology and chronotherapeutics.
大多数生物活动在一天中都会波动，有助于机体更好地适应日常活动。在过去30年里，时间生物学旨在研究这些生物节律，解释以下大部分生物学机制：i）内源性昼夜节律性；ii）允许其外部重置的光系统的神经生理机制；iii）内部节律同步的神经内分泌机制。此外，对细胞甚至分子水平上特定生物节律紊乱和节律问题的描述催生了时辰药理学和时辰治疗学等新兴领域。
