Romon M, Lafay L, Bresson J L, Oppert J-M, Borys J-M, Kettaneh A, Charles M-A
Nutrition Department, University Hospital, 59405 Lille, France.
Int J Obes Relat Metab Disord. 2004 Oct;28(10):1227-32. doi: 10.1038/sj.ijo.0802725.
To study the relationships between physical activity and plasma leptin levels in children from a population-based study, taking into account puberty stages.
Subjects were part of the Fleurbaix-Laventie Ville Santé (FLVS) II Study, a longitudinal study on the determinants of weight gain in children and their parents. At baseline examination, 253 girls and 257 boys aged 8-18 y were examined.
: Height and weight were measured, adiposity was assessed by the sum of four skinfold thicknesses (SSK). Pubertal stage was assigned according to Tanner. Leisure-time physical activity (LTPA) was assessed by the Modifiable Activity Questionnaire and ambulatory activity by pedometer recording over a week. A fasting blood sample was obtained to determine plasma leptin and insulin levels.
Plasma leptin was higher in girls compared to boys (8.3 (1.6-36.5) ng/ml vs 2.2 (0.1-15.3) ng/ml, P<0.001). Multivariate analyses were performed with leptin as dependent variable, and number of steps by day, Tanner stage, insulin and SSK as independent variables. In girls, leptin was negatively correlated to number of steps/day (P<0.001) and positively to SSK (P<0.001) and insulinemia (P<0.001). In boys, leptin was correlated to insulinemia (P<0.001), SSK (P<0.001), Tanner stage (P<.0001), but not to physical activity.
Physical activity is negatively related to leptin levels in girls only and this association is independent of fasting plasma insulin. In children, fasting insulinemia remains associated with leptin levels after taking into account adiposity, physical activity and Tanner stage.
在一项基于人群的研究中，考虑青春期阶段，研究儿童身体活动与血浆瘦素水平之间的关系。
受试者是弗勒尔拜-拉文蒂健康城市（FLVS）II研究的一部分，这是一项关于儿童及其父母体重增加决定因素的纵向研究。在基线检查时，对253名8至18岁的女孩和257名男孩进行了检查。
测量身高和体重，通过四个皮褶厚度之和（SSK）评估肥胖程度。根据坦纳标准确定青春期阶段。通过可修改活动问卷评估休闲时间身体活动（LTPA），通过计步器记录一周的日常活动。采集空腹血样以测定血浆瘦素和胰岛素水平。
女孩的血浆瘦素水平高于男孩（8.3（1.6 - 36.5）ng/ml对2.2（0.1 - 15.3）ng/ml，P<0.001）。以瘦素为因变量，每日步数、坦纳阶段、胰岛素和SSK为自变量进行多变量分析。在女孩中，瘦素与每日步数呈负相关（P<0.001），与SSK呈正相关（P<0.001），与胰岛素血症呈正相关（P<0.001）。在男孩中，瘦素与胰岛素血症（P<0.001）、SSK（P<0.001）、坦纳阶段（P<.0001）相关，但与身体活动无关。
身体活动仅与女孩的瘦素水平呈负相关，且这种关联独立于空腹血浆胰岛素水平。在儿童中，考虑到肥胖、身体活动和坦纳阶段后，空腹胰岛素血症仍与瘦素水平相关。
