急性淋巴细胞白血病患儿谷胱甘肽S-转移酶M1和T1的基因多态性分析
Genetic polymorphisms analysis of glutathione S-transferase M1 and T1 in children with acute lymphoblastic leukemia.
作者信息
Wang Jun, Zhang Li, Feng Jianfei, Wang Hong, Zhu Shaoxian, Hu Yu, Li Yuxiang
机构信息
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
出版信息
J Huazhong Univ Sci Technolog Med Sci. 2004;24(3):243-4. doi: 10.1007/BF02832001.
The relationship between glutathione S-transferases (GSTs) M1, T1 genotype and childhood acute lymphoblastic leukemia (ALL) was investigated. GSTM1 and GSTT1 genotypes in genomic DNA from 67 children with ALL and 146 healthy controls were analyzed by using the multiplex polymerase chain reaction (PCR). The frequencies of GSTM1, M1-T1 null genotypes in ALL children were significantly higher than in the healthy controls (76.12% versus 52.74%, OR=2.856, P<0.001; 50.74% versus 24.66%, OR=3.148, P<0.001, respectively). However, there was no significant relationship between GSTT1 null genotype and ALL of children (61.19% versus 49.32%, OR=1.621, P>0.05). It was suggested that GSTM1 null genotype might be a risk genotype of childhood ALL, while there as no correlation between GSTT1 null genotype and childhood ALL.
研究了谷胱甘肽S-转移酶（GSTs）M1、T1基因型与儿童急性淋巴细胞白血病（ALL）之间的关系。采用多重聚合酶链反应（PCR）分析了67例ALL患儿和146例健康对照者基因组DNA中的GSTM1和GSTT1基因型。ALL患儿中GSTM1、M1-T1缺失基因型的频率显著高于健康对照者（分别为76.12%对52.74%，OR = 2.856，P < 0.001；50.74%对24.66%，OR = 3.148，P < 0.001）。然而，GSTT1缺失基因型与儿童ALL之间无显著关系（61.19%对49.32%，OR = 1.621，P > 0.05）。提示GSTM1缺失基因型可能是儿童ALL的风险基因型，而GSTT1缺失基因型与儿童ALL无相关性。
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