Hu Ting, Zhou Guozhong, Li Wenjin
Department of Hematology, Pingxiang People's Hospital, Pingxiang, China.
Department of Cardiology, Pingxiang People's Hospital, Pingxiang, China.
Front Genet. 2022 Jul 22;13:898937. doi: 10.3389/fgene.2022.898937. eCollection 2022.
Fourteen meta-analyses reported the individual effects of the and polymorphisms on leukemia risk. However, over 40 studies were not included in previously published meta-analyses. Moreover, one key aspect was that previous meta-analyses did not conduct the false-positive test on the aforementioned issues. Furthermore, previous meta-analyses did not observe the combined effects of present/null and present/null polymorphism with leukemia risk. Therefore, we conducted the current study to further analyze these associations. This study aimed to investigate the association between the individual and combined effects of the present/null and present/null polymorphisms and the risk of leukemia. A meta-analysis was performed applying Meta-analyses of Observational Studies in Epidemiology (MOOSE) guidelines. Moreover, false-positive report probability (FPRP) and Bayesian false discovery probability (BFDP) were applied to investigate the false-positive results. The individual and null genotypes and combined effects of the two genes were associated with a significantly increased leukemia risk in overall and several subgroup analyses, such as Asians, Caucasians, and so on. Then, further analysis was conducted using FPRP and BFDP. Significant associations were considered as "positive" results on the null genotype with leukemia risk in overall populations (FPRP < 0.001 and BFDP = 0.006), Asians (FPRP < 0.001 and BFDP < 0.001), and East Asian population (FPRP < 0.001 and BFDP = 0.002). For the null genotype, significant associations were regarded "positive" results in overall populations, acute myeloid leukemia (AML), Asians, and East Asian population. For the combined effects of the and polymorphisms, significant associations were also considered "positive" results in the overall analysis of Asians, Indians, and East Asian population. This study strongly indicates that the individual and null genotypes and combined effects of the two genes are associated with increased leukemia risk in Asians, especially in the East Asian population; the null genotype is associated with increased AML risk; the combined effects of the two genes are associated with increased leukemia risk in Indians.
十四项荟萃分析报告了[具体基因1]和[具体基因2]多态性对白血病风险的个体影响。然而，超过40项研究未被纳入先前发表的荟萃分析中。此外，一个关键问题是先前的荟萃分析未对上述问题进行假阳性检验。此外，先前的荟萃分析未观察到[具体基因1]存在/缺失和[具体基因2]存在/缺失多态性与白血病风险的联合效应。因此，我们进行了本研究以进一步分析这些关联。本研究旨在调查[具体基因1]存在/缺失和[具体基因2]存在/缺失多态性的个体及联合效应与白血病风险之间的关联。我们按照流行病学观察性研究的荟萃分析（MOOSE）指南进行了荟萃分析。此外，应用假阳性报告概率（FPRP）和贝叶斯假发现概率（BFDP）来调查假阳性结果。在总体及几个亚组分析中，如亚洲人、高加索人等，[具体基因1]的个体存在/缺失基因型以及两个基因的联合效应与白血病风险显著增加相关。然后，使用FPRP和BFDP进行了进一步分析。在总体人群（FPRP < 0.001且BFDP = 0.006）、亚洲人（FPRP < 0.001且BFDP < 0.001）以及东亚人群（FPRP < 0.001且BFDP = 0.002）中，[具体基因1]存在/缺失基因型与白血病风险的显著关联被视为“阳性”结果。对于[具体基因2]存在/缺失基因型，在总体人群、急性髓系白血病（AML）、亚洲人和东亚人群中的显著关联被视为“阳性”结果。对于[具体基因1]和[具体基因2]多态性的联合效应，在亚洲人、印度人和东亚人群的总体分析中，显著关联也被视为“阳性”结果。本研究有力地表明，[具体基因1]和[具体基因2]的个体存在/缺失基因型以及两个基因的联合效应与亚洲人，尤其是东亚人群中白血病风险增加相关；[具体基因2]存在/缺失基因型与AML风险增加相关；两个基因的联合效应与印度人白血病风险增加相关。
