Schumann Roman, Hudcova Jana
Department of Anesthesia, Tufts University School of Medicine, Tufts-New England Medical Center, Boston, MA 02111, USA.
Acta Obstet Gynecol Scand. 2004 Sep;83(9):861-2. doi: 10.1111/j.0001-6349.2004.00556.x.
Pruritus, an early symptom of intrahepatic cholestasis of pregnancy, may be severe. Conventional treatment includes ursodeoxycholic acid and cholestyramine. Ondansetron, a 5-hydroxytryptamine 3 receptor antagonist antiemetic, has been shown to reduce pruritus of different etiologies including cholestasis. We now report the successful preoperative use of ondansetron in a patient with pruritus from intrahepatic cholestasis of pregnancy. While the mechanism for our patient's response is poorly understood, 5-hydroxytryptamine 3 receptor antagonists should be further evaluated and possibly considered as a treatment option for intrahepatic cholestasis of pregnancy-related pruritus.
