妊娠期肝内胆汁淤积症
Intrahepatic cholestasis of pregnancy.
作者信息
Geenes Victoria, Williamson Catherine
出版信息
World J Gastroenterol. 2009 May 7;15(17):2049-66. doi: 10.3748/wjg.15.2049.
Abstract
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICP.
摘要
妊娠期肝内胆汁淤积症（ICP）是一种妊娠期特有的肝脏疾病，其特征为孕晚期孕妇出现瘙痒、血清胆汁酸升高以及不良胎儿结局发生率增加。ICP的病因复杂，尚未完全明确，但可能是由于生殖激素及其代谢产物对具有遗传易感性的女性产生胆汁淤积作用所致。胎儿并发症发生的机制同样尚不明确。本文综述了ICP的流行病学、临床特征、诊断、病因及管理。
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