Jonassen A A, Petersen A J, Mohr S, Andersson C, Skattum J, Kvernebo K, Paulsen O G, Stokland O, Kirkebøen K A
Department of Anaesthesia, Section for Cardiothoracic Anaesthesia, Ulleval University Hospital, Oslo, Norway.
Acta Anaesthesiol Scand. 2004 Sep;48(8):1062-5. doi: 10.1111/j.0001-5172.2004.00451.x.
A 56-year old man was admitted for elective mitral valve repair and coronary artery bypass surgery due to mitral valve leakage and unstable angina. After induction of anaesthesia he developed a combined metabolic and respiratory acidosis. Different diagnosis were considered and we decided to treat the patient with dantrolene due to suspicion of malignant hyperthermia (MH). The patient received one dose of dantrolene 2,5 mg/kg during cardiopulmonary bypass (CPB) and a second dose of dantrolene 2,5 mg/kg during weaning from CPB. The first arterial blood gas sample taken in the intensive care unit showed relapse of the acidosis and we administered an infusion of 150 mg dantrolene over 3 hours. The patient gradually recovered without sequel and MH was verified by muscle biopsy testing.
一名56岁男性因二尖瓣反流和不稳定型心绞痛入院接受择期二尖瓣修复和冠状动脉搭桥手术。麻醉诱导后，他出现了混合性代谢性和呼吸性酸中毒。考虑了不同的诊断，由于怀疑恶性高热（MH），我们决定用丹曲林治疗该患者。患者在体外循环（CPB）期间接受了一剂2.5mg/kg的丹曲林，在脱离CPB期间接受了第二剂2.5mg/kg的丹曲林。在重症监护病房采集的第一份动脉血气样本显示酸中毒复发，我们在3小时内输注了150mg丹曲林。患者逐渐康复且无后遗症，通过肌肉活检检测证实为MH。
