Lindblad Erik B
Adjuvant Dept. Brenntag Biosector, DK-3600 Frederikssund, Denmark.
Vaccine. 2004 Sep 9;22(27-28):3658-68. doi: 10.1016/j.vaccine.2004.03.032.
Aluminium compounds have been used as adjuvants in practical vaccination for more than 60 years to induce an early, an efficient and a long lasting protective immunity and are at present the most widely used adjuvants in both veterinary and human vaccines. Although the last two decades of systematic research into the nature of these adjuvants has contributed significantly to understanding their nature and their limitations as Th2 stimulators the more detailed mode of action of these adjuvants is still not completely understood. We have a comprehensive record of their behaviour and performance in practical vaccination, but an empirical approach to optimising their use in new vaccine formulations is still to some extent a necessity. The aim of the present review is to put the recent findings into a broader perspective to facilitate the application of these adjuvants in general and experimental vaccinology.
铝化合物作为佐剂用于实际疫苗接种已有60多年，以诱导早期、高效和持久的保护性免疫，目前是兽用和人用疫苗中使用最广泛的佐剂。尽管过去二十年对这些佐剂性质的系统研究极大地有助于理解其性质以及作为Th2刺激剂的局限性，但这些佐剂更详细的作用方式仍未完全明了。我们对它们在实际疫苗接种中的行为和性能有全面记录，但在某种程度上仍有必要采用经验方法来优化它们在新疫苗配方中的使用。本综述的目的是将近期研究结果置于更广阔的背景下，以促进这些佐剂在一般疫苗学和实验疫苗学中的应用。
