Sumelahti Marja-Liisa, Pukkala Eero, Hakama Matti
University of Tampere, School of Public Health, FI-33101 Tampere, Finland.
Neuroepidemiology. 2004 Sep-Oct;23(5):224-7. doi: 10.1159/000079947.
The risk of cancer among multiple sclerosis (MS) patients was evaluated emphasising cancers with a potentially infectious aetiology. Cancer incidence was estimated among incident MS patients in 1964-1993 (n = 1,597) in Finland. The cohort was followed up for cancer incidence through the Finnish Cancer Registry until 1999. A total of 85 cancer cases were diagnosed showing a standardised incidence ratio (SIR) of 1.0 (95% CI 0.8-1.2) for all cancers. The risk (SIR) of haematological tumours was 1.1 and that of central nervous system (CNS) tumours 1.3. The small excess risk of haematological malignancies is consistent with infectious aetiology, whereas the association between MS and CNS tumours may be due to misclassification.
对多发性硬化症（MS）患者的癌症风险进行了评估，重点关注具有潜在感染病因的癌症。在芬兰，对1964年至1993年期间确诊的MS患者（n = 1,597）的癌症发病率进行了估计。通过芬兰癌症登记处对该队列进行随访，直至1999年，以了解癌症发病率。共诊断出85例癌症病例，所有癌症的标准化发病率（SIR）为1.0（95%CI 0.8 - 1.2）。血液系统肿瘤的风险（SIR）为1.1，中枢神经系统（CNS）肿瘤的风险为1.3。血液系统恶性肿瘤的小幅超额风险与感染病因一致，而MS与CNS肿瘤之间的关联可能是由于分类错误。
