红细胞C3b受体（CR1）活性降低是否有助于耶尔森菌引发的反应性关节炎的发病机制？
Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis?
作者信息
Lahesmaa R, Eerola E, Toivanen A
机构信息
Department of Medical Microbiology, Turku University, Finland.
出版信息
Ann Rheum Dis. 1992 Jan;51(1):97-100. doi: 10.1136/ard.51.1.97.
Abstract
Erythrocyte C3b receptor (CR1) activity was measured in 27 patients with yersinia triggered reactive arthritis and in 151 control subjects, including 36 patients with uncomplicated yersiniosis and 115 healthy subjects. CR1 was measured by the immune adherence haemagglutination method. Patients with yersinia triggered reactive arthritis had reduced levels of CR1 compared with the controls. This difference was mainly due to the finding that five out of six HLA B27 negative patients with arthritis had decreased CR1 activity. Such a quantitative difference may contribute to the pathogenesis of reactive arthritis by affecting the clearance of immune complexes.
摘要
对27例耶尔森菌引发的反应性关节炎患者以及151名对照者（包括36例非复杂性耶尔森菌病患者和115名健康受试者）的红细胞C3b受体（CR1）活性进行了检测。采用免疫黏附血凝法检测CR1。与对照组相比，耶尔森菌引发的反应性关节炎患者的CR1水平降低。这种差异主要是由于发现6例HLA B27阴性关节炎患者中有5例CR1活性降低。这种数量差异可能通过影响免疫复合物的清除而促使反应性关节炎的发病机制。
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