Sindern Eckhart, Patzold Tanja, Ossege Ludgera Manuela, Gisevius Astrid, Malin Jean Pierre
Department of Neurology, Ruhr University, BG-Kliniken Bergmannsheil, Bürkle-de-la-Camp Platz 1, 44789, Bochum, Germany.
J Neuroimmunol. 2002 Oct;131(1-2):186-90. doi: 10.1016/s0165-5728(02)00263-1.
We evaluated CXCR3 expression on T-cells and levels of its ligand CXCL10 in blood and cerebrospinal fluid (CSF) of 22 patients with relapsing-remitting multiple sclerosis (RR-MS) in association with magnetic resonance imaging (MRI) disease activity. CXCL10 was strongly released intrathecally, but did not change in association with MRI activity. CXCR3 expression on T-cells was lower in the peripheral blood (PB) of RR-MS patients compared to healthy controls and was increased in the CSF of RR-MS patients undergoing acute attacks, as illustrated by Gd-enhancing lesions on MRI, compared to patients without enhancing lesion. Our results suggest that MRI-documented disease activity is associated with an increase of CXCR3 positive T-cells in the CSF, possibly due to the migration of activated T-cells from the circulation into the CSF.
我们评估了22例复发缓解型多发性硬化症（RR-MS）患者的T细胞上CXCR3的表达及其血液和脑脊液（CSF）中配体CXCL10的水平，并将其与磁共振成像（MRI）疾病活动相关联。CXCL10在鞘内大量释放，但与MRI活动无关。与健康对照相比，RR-MS患者外周血（PB）中T细胞上的CXCR3表达较低，并且与MRI上出现钆增强病变的RR-MS急性发作患者的CSF相比，无增强病变的患者CSF中CXCR3表达增加。我们的结果表明，MRI记录的疾病活动与CSF中CXCR3阳性T细胞的增加有关，这可能是由于活化的T细胞从循环系统迁移到CSF中所致。
