Dewhurst Stephen
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA.
Herpes. 2004 Jun;11 Suppl 2:105A-111A.
In developing guidelines for the improved management of herpesvirus infections of the central nervous system (CNS), the International Herpes Management Forum (IHMF) has considered human herpesvirus (HHV) type 6 and type 7 disease. Although HHV-6 is generally asymptomatic, it has been associated with exanthema subitum, febrile convulsions and encephalitis in infants and immunocompromised adults and may play a role in multiple sclerosis, Guillain-Barre syndrome and acute disseminated encephalomyelitis. As HHV-6 is present in the brain tissue of healthy individuals, its role as an aetiological agent in CNS disorders is unclear. While polymerase chain reaction (PCR) is a method useful for diagnosis of other viral CNS infections, it has no value for diagnosing HHV-6. HHV-7 has not been shown to cause a specific disease but is associated with febrile convulsions and has been implicated as a cause of encephalitis. Ganciclovir and foscarnet, either alone or in combination, may be used for the management of HHV-6-related neurological disease. Although ganciclovir is unlikely to be effective against HHV-7-related CNS disease, foscarnet may be useful but prospective trials are needed.
在制定改善中枢神经系统（CNS）疱疹病毒感染管理的指南时，国际疱疹管理论坛（IHMF）已考虑了6型和7型人类疱疹病毒（HHV）疾病。虽然HHV-6通常无症状，但它与幼儿急疹、热性惊厥以及婴儿和免疫功能低下成人的脑炎有关，并且可能在多发性硬化症、格林-巴利综合征和急性播散性脑脊髓炎中起作用。由于HHV-6存在于健康个体的脑组织中，其作为中枢神经系统疾病病原体的作用尚不清楚。虽然聚合酶链反应（PCR）是诊断其他病毒性中枢神经系统感染的有用方法，但它对诊断HHV-6没有价值。尚未证明HHV-7会引起特定疾病，但它与热性惊厥有关，并被认为是脑炎的病因之一。更昔洛韦和膦甲酸钠单独使用或联合使用，可用于治疗与HHV-6相关的神经系统疾病。虽然更昔洛韦不太可能对与HHV-7相关的中枢神经系统疾病有效，但膦甲酸钠可能有用，但需要进行前瞻性试验。
