Kiessling Justine, Martin Anja, Gremillon Louis, Rensing Stefan A, Nick Peter, Sarnighausen Eric, Decker Eva L, Reski Ralf
Plant Biotechnology, University of Freiburg, Schaenzlestrasse 1, D-79104 Freiburg, Germany.
EMBO Rep. 2004 Sep;5(9):889-94. doi: 10.1038/sj.embor.7400238.
FtsZ is a filament-forming protein that assembles into a ring at the division site of prokaryotic cells. As FtsZ and tubulin share several biochemical and structural similarities, FtsZ is regarded as the ancestor of tubulin. Chloroplasts--the descendants of endosymbiotic bacteria within plant cells--also harbour FtsZ. In contrast to eubacteria, plants have several different FtsZ isoforms. So far, these isoforms have only been implicated with filamentous structures, rings and networks, inside chloroplasts. Here, we demonstrate that a novel FtsZ isoform in the moss Physcomitrella patens is located not only in chloroplasts but also in the cytoplasm, assembling into rings in both cell compartments. These findings comprise the first report on cytosolic localization of a eukaryotic FtsZ isoform, and indicate that this protein might connect cell and organelle division at least in moss.
FtsZ是一种能形成细丝的蛋白质，它在原核细胞的分裂位点组装成一个环。由于FtsZ与微管蛋白在生物化学和结构上有若干相似之处，FtsZ被视为微管蛋白的祖先。叶绿体——植物细胞内共生细菌的后代——也含有FtsZ。与真细菌不同，植物有几种不同的FtsZ同工型。到目前为止，这些同工型仅与叶绿体内的丝状结构、环和网络有关。在此，我们证明，苔藓小立碗藓中的一种新型FtsZ同工型不仅位于叶绿体中，也位于细胞质中，且在这两个细胞区室中都组装成环。这些发现是关于真核生物FtsZ同工型胞质定位的首次报道，并表明这种蛋白质可能至少在苔藓中连接细胞和细胞器的分裂。
