胡芦巴油对四氯化碳诱导的大鼠肝损伤的保肝活性。
Hepatoprotective activity of Haridradi ghrita on carbon tetrachloride-induced liver damage in rats.
作者信息
Satturwar P M, Fulzele S V, Joshi S B, Dorle A K
机构信息
Department of Pharmaceutical Sciences, Nagpur University Campus, Amravati Road, Nagpur 440 010, India.
出版信息
Indian J Exp Biol. 2003 Dec;41(12):1447-51.
Haridradi ghrita, a ghee based polyherbal formulation, (50, 100, 200 and 300 mg/kg) significantly lowered marker enzymes (SGPT, SGOT, ALP) and bilirubin in serum and liver peroxide, superoxide dismutase and catalase in liver homogenate following CCl4 (0.7 ml/kg, ip) toxicity. The protective effect was further supported by reversal of CCl4 induced histological changes. The results demonstrate significant hepatoprotective action of H. ghrita in CCl4 damaged rats.
哈里德拉迪酥油（Haridradi ghrita）是一种基于酥油的多草药配方制剂（50、100、200和300毫克/千克），在四氯化碳（0.7毫升/千克，腹腔注射）毒性作用后，能显著降低血清中的标志物酶（谷丙转氨酶、谷草转氨酶、碱性磷酸酶）和胆红素，以及肝匀浆中的肝过氧化物、超氧化物歧化酶和过氧化氢酶。四氯化碳诱导的组织学变化的逆转进一步支持了这种保护作用。结果表明，哈里德拉迪酥油对四氯化碳损伤的大鼠具有显著的肝保护作用。
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